Guarding the Bcl-2 Army

Bcl-2

Recent findings from our laboratory provide the first indication that overexpression of Bcl-2 in Eµ-myc transgenic cells enhances tumor immunosurveillance by inducing NKG2D ligands. Initial evidence suggests that this model is relevant to human patients. Thus, antitumor therapies that target Bcl-2 harbor the risk of reducing tumor immunogenicity.

BCL 2 L 11 ( BCL 2 - like 11 ( apoptosis facilitator ) )

Other names: BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL HGNC (Hugo): BCL2L11 Location: 2q13 Local order: According to GeneLoc and NCBI Map Viewer, genes flanking BCL2L11 in plus strand direction are: ACOXL 2q13 (acyl-Coenzyme A oxidase-like); PAFAH1P2 2q13 (platelet-activating factor acetylhydrolase, isoform Ib, pseudogene 2). Note: BCL2L11/BIM is a BH3-only protein from the B...

Guarding Art Galleries by Guarding Witnesses

Let P be a simple polygon. We define a witness set W to be a set of points such that if any (prospective) guard set G guards W , then it is guaranteed that G guards P . We show that not all polygons admit a finite witness set. If a finite minimal witness set exists, then it cannot contain any witness in the interior of P ; all witnesses must lie on the boundary of P , and there can be at most o...

Guarding the Body

Guarding the Gate

BACKGROUND Failed treatment trials are common in major depressive disorder and treatment-resistant depression, and remotely performed multifaceted, centralized structured interviews can potentially enhance signal detection by ensuring that enrolled patients meet eligibility criteria. METHODS We assessed the use of a specific remote structured interview that validated the diagnosis, level of t...